Admission Levels Of Interleukin 10 And Amyloid Β 1 40 Improve The Outcome Prediction Performance Of The Helsinki Computed Tomography Score In Traumatic Brain Injury Pmc

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JP has received a speaker’s fee from the Finnish Medical Association. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor is currently organizing a Research Topic with some of the authors OT and J-CS.

Table 7

The results presented here suggest that protein biomarkers IL-10 and Aβ40 provide incremental value in outcome prediction when used in combination with the HCTS. In line with this finding, it has been previously reported that most of the clinical studies have not identified a correlation between blood IL-10 levels and GCS scores (33). We have recently reported IL-10 thresholds of 0.38 and 0.44 pg/ml depending on other markers included in the panels for predicting unfavorable outcomes. Correspondingly, when the HCTS is included in the panels, IL-10 thresholds need to be lower to capture patients with low IL-10 levels, low GCS scores, and unfavorable outcomes. The Electroencephalogram (EEG) plays an important role in detecting and localizing seizures, as well as in the diagnosis of epilepsy. 1

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, 47 ML models with natural language processing components might be able to interpret medical records of each patient to better tune the model to detect or predict patient‐specific seizures. Using EMG‐based seizure detection devices attached on specific body parts such as the arms, studies have demonstrated the ability to detect generalized tonic–clonic seizures (GTCS) to detect seizures with sensitivities of more than 90%.

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The only dataset that applied band filtering of between 0.5 and 70 Hz was the Hauz Khas dataset. Each of the segments in TUSZ is pruned to reduce the length of each segment to less than an hour. Noncontinuous datasets generally come with random segmentation, where there are no time relationships between each of the neighboring segments. Noncontinuous datasets that are randomly segmented, such as the University of Bonn, Hauz Khas, and Kaggle datasets, are chosen from the unpublished continuous dataset based on multiple criteria depending on the classification tasks.

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• Differences between groups are analyzed with the Mann–Whitney U-test.

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• This can be seen in studies using where the model with a new circadian component applying long‐term continuous Neurovista dataset performs a lot better than those without that.
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Hence, studies that intend to produce algorithms that are patient‐specific, identifying patient‐specific biomarkers, should avoid the University of Bonn and Hauz Khas datasets. The dataset that contains the largest number of subjects is TUSZ with 592, followed by the Helsinki University Hospital and CHB‐MIT datasets with 79 and 23 subjects, respectively. The TUSZ corpus contains the most variation in terms of EEG characteristics in the recordings. While most recordings obtained originated from human subjects, datasets from Kaggle competitions such as Kaggle UPenn and American Epilepsy Society contain EEG recordings of both human and canine subjects. We adapted the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) guidelines to perform a data search as shown in Figure 1. The search of relevant literature that used an EEG seizure dataset was divided into two parts.

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Regarding the temporal properties of EEG datasets, the length of segments varies across all datasets for both continuous and noncontinuous datasets as shown in Table 8. Within the same dataset itself, the length of each segment is different where each seizure event can be divided into multiple ictal or preictal segments. This can be seen in Table 8, where the Helsinki University Hospital EEG dataset has a median epoch length of 74 minutes, and the Neurovista ictal dataset has different seizure segment lengths, with an average of 107 seconds.

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• Review studies on seizure detection and prediction were also reviewed to search for publicly available datasets that we might have potentially missed.

We investigated the advantages and limitations of the characteristics of the EEG datasets. Based on our study, we identified 17 characteristics that make the EEG datasets unique from each other. The generalized model only learns features and biomarkers present in the current group of patients but might fail to highlight or capture important unique characteristics of certain patients outside the group. However, using larger datasets or multiple datasets for a certain study introduces potential complexity if there are differences in the number of channels or structural properties. To further elucidate the outcome prediction performance of the biomarkers, we also studied patients with CT-negative TBIs (comparison study cohort).

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• When studied alone, the HCTS had the highest pAUCs of the tested covariates, followed by Aβ40 and Aβ42.

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The AUC, demonstrated in Figure 1, confirms the best prediction of the Rotterdam and Helsinki CT scores regarding the Marshall CT class, which presented greater discriminative ability. These two models also presented better calibration, demonstrated by higher Brier Score values (Table 3). Where chemical depends on the particular dataset itself, while b and farrenheit are determined by the particular authors of the research.

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48 , 49 Further, studies have shown that there are significant changes in the heart rate such as tachycardia and increased heart rate variability.

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• The individual specificities of the HCTS and biomarkers remained low (2–33%) in isolation, but the optimal combination panel yielded a specificity of 59% when the sensitivity was set above 90%.
• However, we do not consider this a major limitation, since EEG signals are the main focus and the scalp datasets normally follow the international 10–20 system or the Nomenclature 10–10 system.
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TBI, traumatic brain injury; CT, computerized tomography; AUC, area under the curve; CI, confidence interval. CT, computerized tomography; TBI, traumatic brain injury; tSAH, traumatic subarachnoid hemorrhage. The distribution of preictal, ictal, and interictal class in the datasets. JP, RT, AK, MM, IH, H-RM, JT, PK, and OT collected and curated the data. JP drafted the manuscript with critical contributions from RT, RR, and TL.

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